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Chinese Journal of Organic Chemistry >

2017 , Vol. 37 >Issue 1: 232 - 236

DOI: https://doi.org/10.6023/cjoc201607031

NOTE

Synthesis and Biological Activity of 1,2,4-Triazole Thioether Derivatives Containing Pyrazole Moiety

  • Zhai Zhiwen ,
  • Wang Qiao ,
  • Shen Zhonghua ,
  • Tan Chengxia ,
  • Weng Jianquan ,
  • Liu Xinghai
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  • College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014

Received date: 2016-07-20

  Revised date: 2016-08-25

  Online published: 2016-09-01

Supported by

Project supported by the Zhejiang Provincial Science Foundation of China(No. LY16C14007) and the Research Institute Special Program of Department of Science and Technology of Zhejiang Province(No. 2015F50030).

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Abstract

A series of novel 1,2,4-triazole derivatives were synthesized from ethyl trifluoroacetoacetate,triethyl orthoformate,methylhydrazine,phenyl isothiocyanate by multi-step reactions.Their structures were characterized by 1H NMR,13C NMR,HRMS and X-ray diffraction.The target compounds were evaluated for their fungicidal activity and herbicidal activitiy.The results indicated that some of the title compounds displayed certain fungicidal activities against Colletotrichum orbiculare and herbicidal activity against dicotyledons.

Key words： pyrazole; 1,2,4-triazole; synthesis; fungicidal activity; herbicidal activity

Cite this article

Zhai Zhiwen , Wang Qiao , Shen Zhonghua , Tan Chengxia , Weng Jianquan , Liu Xinghai . Synthesis and Biological Activity of 1,2,4-Triazole Thioether Derivatives Containing Pyrazole Moiety[J]. Chinese Journal of Organic Chemistry, 2017 , 37(1) : 232 -236 . DOI: 10.6023/cjoc201607031

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