Chinese Journal of Organic Chemistry >
Two New Compounds from the Leaves of Paliurus ramosissimus
Received date: 2016-07-29
Revised date: 2016-09-22
Online published: 2016-10-11
Supported by
Project supported by the National Key Technology Research and Development Program of the Science and Technology Department of Sichuan Province (No. 15ZC1978), and the Sichuan Provincial Research Institute of Science and Technology Achievements Transformation Fund (No. 14010139).
To study chemical constituents in the ethanol extract of Paliurus ramosissimus (Lour.) Poir, two new compounds along with four known compounds were isolated and purified by repeated gel column chromatographies and high performance preparative liquid chromatography. On the basis of spectroscopic methods (HR-ESIMS, 1D-and 2D-NMR), their structures were identified as 2α-(cis-p-hydroxy-cinnamyloxy)-3α-hydroxy-27-(trans-p-hydroxy-cinnamyloxy)betulinic acid (1), 2α-(trans-p-hydroxy-cinnamyloxy)-3α-hydroxy-27-(cis-p-hydroxy-cinnamyloxy)betulinic acid (2), messagenic acid A (3), mes-sagenic acid B (4), betulinaldehyde (5) and β-sitosterol (6). Among them, compounds 1 and 2 were new compounds named as paliurusene A and paliurusene B, which belong to triterpenoids, compounds 3~6 were isolated from this plant for the first time. The anti-tumor activity of compounds 1~3 was evaluated by methyl thiazolyl tetrazolium (MTT) assays. The result showed that compounds 1~3 presented obvious cytotoxicity in vitro against the cancer cell lines.
Lu Xinwei , Xie Ying , Wang Jing , Tan Lei , Zhan Yan , Ruan Jia , Xu Chaoqun . Two New Compounds from the Leaves of Paliurus ramosissimus[J]. Chinese Journal of Organic Chemistry, 2017 , 37(2) : 520 -525 . DOI: 10.6023/cjoc201607044
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