Two New Compounds from the Leaves of Paliurus ramosissimus

doi:10.6023/cjoc201607044

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (2): 520-525.DOI: 10.6023/cjoc201607044 Previous Articles Next Articles

NOTE

马甲子叶中两个新化合物

卢辛未^a,b, 谢莹^a,b, 王京^a,b, 谭镭^b, 詹雁^b, 阮佳^b, 徐超群^b

a 成都中医药大学药学院成都 610075;
b 四川省中医药科学院成都 610041

收稿日期:2016-07-29 修回日期:2016-09-22 发布日期:2016-10-11
通讯作者: 徐超群 E-mail:chaoqun_xu@sina.com
基金资助:
四川省科技支撑计划（No.15ZC1978）、四川省科研院所科技成果转化（No.14010139）资助项目.

Two New Compounds from the Leaves of Paliurus ramosissimus

Lu Xinwei^a,b, Xie Ying^a,b, Wang Jing^a,b, Tan Lei^b, Zhan Yan^b, Ruan Jia^b, Xu Chaoqun^b

a School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 610075;
b Institute of Pharmacy, Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041

Received:2016-07-29 Revised:2016-09-22 Published:2016-10-11
Supported by:
Project supported by the National Key Technology Research and Development Program of the Science and Technology Department of Sichuan Province (No. 15ZC1978), and the Sichuan Provincial Research Institute of Science and Technology Achievements Transformation Fund (No. 14010139).

1. Two New Compounds from the Leaves of Paliurus ramosissimus.PDF(1754KB)

Abstract

To study chemical constituents in the ethanol extract of Paliurus ramosissimus (Lour.) Poir, two new compounds along with four known compounds were isolated and purified by repeated gel column chromatographies and high performance preparative liquid chromatography. On the basis of spectroscopic methods (HR-ESIMS, 1D-and 2D-NMR), their structures were identified as 2α-(cis-p-hydroxy-cinnamyloxy)-3α-hydroxy-27-(trans-p-hydroxy-cinnamyloxy)betulinic acid (1), 2α-(trans-p-hydroxy-cinnamyloxy)-3α-hydroxy-27-(cis-p-hydroxy-cinnamyloxy)betulinic acid (2), messagenic acid A (3), mes-sagenic acid B (4), betulinaldehyde (5) and β-sitosterol (6). Among them, compounds 1 and 2 were new compounds named as paliurusene A and paliurusene B, which belong to triterpenoids, compounds 3~6 were isolated from this plant for the first time. The anti-tumor activity of compounds 1~3 was evaluated by methyl thiazolyl tetrazolium (MTT) assays. The result showed that compounds 1~3 presented obvious cytotoxicity in vitro against the cancer cell lines.

Key words: Paliurus ramosissimus (Lour.) Poir., pentacyclic triterpenoids, paliurusene A, paliurusene B, anti-tumor

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Lu Xinwei, Xie Ying, Wang Jing, Tan Lei, Zhan Yan, Ruan Jia, Xu Chaoqun. Two New Compounds from the Leaves of Paliurus ramosissimus[J]. Chin. J. Org. Chem., 2017, 37(2): 520-525.

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马甲子叶中两个新化合物

Two New Compounds from the Leaves of Paliurus ramosissimus

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