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Chinese Journal of Organic Chemistry >

2017 , Vol. 37 >Issue 2: 423 - 428

DOI: https://doi.org/10.6023/cjoc201608003

ARTICLE

Fluorescence Recognition of H2S by a Benzothiazole Derivative and Its Live Cell Imaging

  • He Ping ,
  • Tang Lijun ,
  • Zhong Keli ,
  • Hou Shuhua ,
  • Yan Xiaomei
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  • a College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121013;
    b College of Laboratory Medicine, Dalian Medical University, Dalian 116044

Received date: 2016-08-04

  Revised date: 2016-09-19

  Online published: 2016-10-11

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21476029, U1608222) and the Liaoning Excellent Talents in University (No. LR2015001).

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Abstract

A new benzothiazole-derived fluorescence probe 2-(4-azidobenzyl)oxy-3-(benzo[d]thiazol-2-yl)-5-methylben-zaldehyde (HBTA) was synthesized from 3-(benzo[d]thiazol-2-yl)-2-hydroxy-5-methylbenzaldehyde, and the structure of HBTA was characterized. The recognition behaviors of HBTA to H2S were investigated and the results show that HBTA exhibits good selectivity and sensitivity to H2S with fast response and good anti-interference ability. The probe can be applied to detect H2S in a broad pH range, and the detection limit of HBTA for H2S was estimated to be 9.09×10-7 mol·L-1. Cell imaging studies reveal that HBTA is capable of detect H2S in live cells.

Key words： hydrogen sulfide; fluorescent probe; benzothiazole; cells imaging

Cite this article

He Ping , Tang Lijun , Zhong Keli , Hou Shuhua , Yan Xiaomei . Fluorescence Recognition of H2S by a Benzothiazole Derivative and Its Live Cell Imaging[J]. Chinese Journal of Organic Chemistry, 2017 , 37(2) : 423 -428 . DOI: 10.6023/cjoc201608003

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