Chinese Journal of Organic Chemistry >
Pepsin-Catalyzed Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives
Received date: 2016-06-20
Revised date: 2016-09-17
Online published: 2016-10-18
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21462001, 21465002), the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT13054), the Natural Science Foundation of Jiangxi Province (No. 20142BAB203008).
The catalytic property of some hydrolases for the cyclocondensation of aldehydes with 2-aminobenzamide was researched in alcohol solvent, and pepsin was selected as the best catalyst. The reaction conditions were optimized through investigating the temperature, the enzyme loading, the ratio of substrates and the reaction time. Under the optimal conditions, 5 mg of pepsin could catalyze the cyclizing reaction of aldehydes with 2-aminobenzamide, and the corresponding 2,3-dihydroquinazolin-4(1H)-ones were successfully obtained in high yields.
Xie Zongbo , Zhang Shiguo , Jiang Guofang , Liang Meng , Le Zhanggao . Pepsin-Catalyzed Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives[J]. Chinese Journal of Organic Chemistry, 2017 , 37(2) : 514 -519 . DOI: 10.6023/cjoc201606030
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