Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (2): 514-519.DOI: 10.6023/cjoc201606030 Previous Articles     Next Articles



谢宗波a,b, 张士国b, 姜国芳b, 梁萌b, 乐长高a,b   

  1. a 东华理工大学 江西省质谱科学与仪器2011协同创新中心 南昌 330013;
    b 东华理工大学应用化学系 南昌 330013
  • 收稿日期:2016-06-20 修回日期:2016-09-17 发布日期:2016-10-18
  • 通讯作者: 姜国芳, 乐长高;
  • 基金资助:


Pepsin-Catalyzed Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives

Xie Zongboa,b, Zhang Shiguob, Jiang Guofangb, Liang Mengb, Le Zhanggaoa,b   

  1. a Jiangxi 2011 Joint Center for the Innovative Mass Spectrometry and Instrumentation, East China University of Technology, Nanchang 330013;
    b Department of Applied Chemistry, East China University of Technology, Nanchang 330013
  • Received:2016-06-20 Revised:2016-09-17 Published:2016-10-18
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21462001, 21465002), the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT13054), the Natural Science Foundation of Jiangxi Province (No. 20142BAB203008).

The catalytic property of some hydrolases for the cyclocondensation of aldehydes with 2-aminobenzamide was researched in alcohol solvent, and pepsin was selected as the best catalyst. The reaction conditions were optimized through investigating the temperature, the enzyme loading, the ratio of substrates and the reaction time. Under the optimal conditions, 5 mg of pepsin could catalyze the cyclizing reaction of aldehydes with 2-aminobenzamide, and the corresponding 2,3-dihydroquinazolin-4(1H)-ones were successfully obtained in high yields.

Key words: 2-aminobenzamide, aldehyde, cyclocondensation, 2,3-dihydroquinazolin-4(1H)-ones, pepsin