Chinese Journal of Organic Chemistry >
Convenient Synthesis of Imidazo-Fused Heterocycles via CeCl3·7H2O Catalyzed Groebke-Blackburn-Bienayme Reaction
Received date: 2017-01-10
Revised date: 2017-02-12
Online published: 2017-02-20
Supported by
Project supported by the National Natural Science Foundation of China (No. 30873140), the Program for Excellent Talents of Beijing City (No. 20071D0501600227) and the Beijing Municipal Commission of Education (No. KM201010028011).
A simple, efficient and eco-friendly “one-pot” method for the convenient synthesis of imidazo-fused heterocycles has been developed. The reaction was catalyzed by CeCl3·7H2O in ethanol under 60 ℃ via Groebke-Blackburn-Bienayme (GBB) reaction of aldehydes, aminoazines and isocyanides. This method has many advantages of a wide range of substrates, short reaction time and easy purification. In addition, we conducted a comparative study of LaCl3·7H2O with CeCl3·7H2O on their catalytic effect under the same reaction conditions, and found that CeCl3·7H2O was comparable to LaCl3·7H2O as catalyst in GBB reaction.
Zhang Zhaorui , Xu Liang , Tang Hanqin , Wu Boxin , Feng Di , Guo Changbin . Convenient Synthesis of Imidazo-Fused Heterocycles via CeCl3·7H2O Catalyzed Groebke-Blackburn-Bienayme Reaction[J]. Chinese Journal of Organic Chemistry, 2017 , 37(5) : 1252 -1257 . DOI: 10.6023/cjoc201701024
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