Chinese Journal of Organic Chemistry >
Tin-Promoted One-Pot Synthesis of Aryl/Trifluoromethyl Group Substituted Homoallylic N-Acylhydrazines
Received date: 2016-12-13
Revised date: 2017-03-01
Online published: 2017-03-14
Supported by
Project supported by the National Natural Science Foundation of China (Nos.21262031,21462037).
A series of trifluoromethylated homoallylic N-acylhydrazines were obtained from one-pot reaction of aryl trifluoroketones, acylhydrazines and allyl bromide promoted by tin powder in the presence of boron trifluoride diethyl etherate (BF3·OEt2). The features of this process include good yields, wide substrate scope, mild conditions and easy operation. Trifluoromethylated homoallylic N-acylhydrazines are useful trifluoromethyl building blocks. They can be easily transformed into trifluoromethylated nitrogen-containing compounds.
Wang Kehu , Wang Yalin , Yin Xuejiao , Peng Xiansha , Huang Danfeng , Su Yingpeng , Hu Yulai . Tin-Promoted One-Pot Synthesis of Aryl/Trifluoromethyl Group Substituted Homoallylic N-Acylhydrazines[J]. Chinese Journal of Organic Chemistry, 2017 , 37(7) : 1764 -1773 . DOI: 10.6023/cjoc201612042
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