Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (7): 1764-1773.DOI: 10.6023/cjoc201612042 Previous Articles     Next Articles



王克虎, 王雅琳, 殷雪娇, 彭先沙, 黄丹凤, 苏瀛鹏, 胡雨来   

  1. 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2016-12-13 修回日期:2017-03-01 发布日期:2017-03-14
  • 通讯作者: 王克虎, 胡雨来;
  • 基金资助:


Tin-Promoted One-Pot Synthesis of Aryl/Trifluoromethyl Group Substituted Homoallylic N-Acylhydrazines

Wang Kehu, Wang Yalin, Yin Xuejiao, Peng Xiansha, Huang Danfeng, Su Yingpeng, Hu Yulai   

  1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2016-12-13 Revised:2017-03-01 Published:2017-03-14
  • Contact: 10.6023/cjoc201612042;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.21262031,21462037).

A series of trifluoromethylated homoallylic N-acylhydrazines were obtained from one-pot reaction of aryl trifluoroketones, acylhydrazines and allyl bromide promoted by tin powder in the presence of boron trifluoride diethyl etherate (BF3·OEt2). The features of this process include good yields, wide substrate scope, mild conditions and easy operation. Trifluoromethylated homoallylic N-acylhydrazines are useful trifluoromethyl building blocks. They can be easily transformed into trifluoromethylated nitrogen-containing compounds.

Key words: one-pot, tin powder, aryl trifluoroketones, trifluoromethylated homoallylic N-acylhydrazines