Chinese Journal of Organic Chemistry >
Study of the Synthesis of α-Alkoxycarbonylaminomethylphosphonates
Received date: 2017-01-25
Revised date: 2017-03-08
Online published: 2017-04-13
Supported by
Project supported by the National Natural Science Foundation of China (No. 21462056), the Science and Technology Foundation of Guizhou Province (No.[2014]7542), and the Education Department of Guizhou Province (No. 201610661006).
Methods for the synthesis of α-alkoxycarbonylaminomethylphosphonates are very limited because of the presence of unique methylene group in their structures. Thus the methodology for the synthesis of this kind of compounds is studied. Under the basic conditions of using LiOH, α-sulfonylmethylcarbamates reacted with dialkylphosphonates in the solvent of commercial EtOAc giving the products of α-alkoxycarbonylaminomethylphosphonates which are typically hard to be synthesized in good to moderate yields. This simple protocol runs under very mild conditions, and can be exploited for multigram amounts with good yield too.
Huang Xiaoli , Ren Linjing , Ali Sajjad , Pu Jiazhi , Yao Qiuli . Study of the Synthesis of α-Alkoxycarbonylaminomethylphosphonates[J]. Chinese Journal of Organic Chemistry, 2017 , 37(8) : 2073 -2077 . DOI: 10.6023/cjoc201701047
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