Chinese Journal of Organic Chemistry >
Synthesis of 3,4-Diaryl-5-aryloxymethyl Isoxazole Derivatives
Received date: 2017-02-20
Revised date: 2017-04-07
Online published: 2017-05-25
Supported by
Project supported by the National Natural Science Foundation of China (No. 21272153).
Due to isoxazole derivatives possess a wide range of herbicidal, insecticidal and pharmacological activitives, the synthetic methodologies for preparation of isoxazole derivatives have drawn much attention in recent years. Herein, 3,4-diaryl-5-aryloxymethyl isoxazole derivatives were effectively synthesized from 3-aryl-5-(bromomethyl)isoxazole via consecutive bromination, etherification, followed by Suzuki coupling reaction catalyzed by Pd(PPh3)2Cl2. Preliminary bioassay data showed that some of the title compounds exhibited certain insecticidal activities against Oriental armyworm.
Jiang Haifang , Zhang Min , Zhang Li , Chen Yali , Zhu Ning , Song Liping , Deng Hongmei . Synthesis of 3,4-Diaryl-5-aryloxymethyl Isoxazole Derivatives[J]. Chinese Journal of Organic Chemistry, 2017 , 37(9) : 2399 -2408 . DOI: 10.6023/cjoc201702026
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