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Chinese Journal of Organic Chemistry >

2017 , Vol. 37 >Issue 10: 2763 - 2766

DOI: https://doi.org/10.6023/cjoc201705035

NOTE

Clerodane Diterpenes from the Roots of Polyalthia laui

  • Li Xiaobao ,
  • Chen Guangying ,
  • Shao Taiminga ,
  • Song Xiaoping ,
  • Han Changri ,
  • Yu Zhangxin
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  • a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158;
    b Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, School of Chemical and Material Engineering, Hainan Institute of Science and Technology, Haikou 571126

Received date: 2017-05-23

  Revised date: 2017-06-10

  Online published: 2017-06-23

Supported by

Project supported by the National Natural Science Foundation of China (Nos.81160391,21362009,81360478),the International S&T Cooperation Program of China (No.2014DFA40850),the Program for Innovative Research Team in University (No.IRT-16R19),the Hainan Provincal Natural Science Foundation of Innovatie Research Team Project (No.2016CXTD007) and the Natural Science Foundation of Hainan Province (No.20162031).

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Abstract

Five clerodane diterpenes were isolated from the roots of Polyalthia laui during a systematic phytochemical investigation. Their structures were elucidated by the NMR and HRMS data as methyl (4→2)-abeo-2,13-diformyl-cleroda-2,12E-dien-15-ate (1), (E)-ent-cleroda-3,12-diene-15,16-dioic acid (2), 14,15-dinorclerod-3-ene-2,13-dione (3), solidagolactone (4), and 16-hydroxy-3,13Z-kolavadien-16,15-olide (5). Among them, compounds 1~2 are new clerodane diterpenes. Biological evaluation of compounds 1~5 against human Hela, A549, MCF-7 and HL-60 human cancer cell lines showed that all com-pounds displayed moderate cytotoxicities against various human cancer cell lines with IC50 ranged from 13.22 to 37.16 μmol/L.

Key words： Polyalthia laui; clerodane diterpenes; cytotoxicities

Cite this article

Li Xiaobao , Chen Guangying , Shao Taiminga , Song Xiaoping , Han Changri , Yu Zhangxin . Clerodane Diterpenes from the Roots of Polyalthia laui[J]. Chinese Journal of Organic Chemistry, 2017 , 37(10) : 2763 -2766 . DOI: 10.6023/cjoc201705035

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