Chinese Journal of Organic Chemistry >
Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Substituted Tetrazolyl Group
Received date: 2017-08-13
Revised date: 2017-09-06
Online published: 2017-09-26
Supported by
Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), and Postgraduate Research and Practice Innovation Program of Jiangsu Province (No. SJCX17_0640).
In order to explore novel pyrazole oxime derivatives with potent biological activities, a series of novel pyrazole oximes carrying tetrazole unit were designed and synthesized by the method of active substructure combination. The structures of the title compounds were confirmed by 1H NMR,13C NMR, and elemental analysis. Preliminary bioassay data showed that some aimed compounds displayed good insecticidal activities. At the concentration of 500 μg/mL, ten compounds exhibited insecticidal activity against Oriental armyworm with 90%~100%, nine compounds had insecticidal activity against Aphis medicaginis with 80%~100%, ten compounds possessed insecticidal activity against Nilaparvata lugens with 80%~100%, and one compound exhibited 80% acaricidal activity against Tetranychus cinnabarinus. When the concentration was reduced to 100 μg/mL, one compound still showed insecticidal activity against Aphis medicaginis with 85%. Additionally, some compounds had certain fungicidal activity, at 200 μg/mL two compounds showed 60%~80% fungicidal activity against Pseudoperonospora cubensis.
Key words： tetrazole; pyrazole oxime; synthesis; biological activity
Dai Hong , Yao Wei , Du Xianchao , Wang Xianglong , Wu Jinming , Chen Qingwen , Li Chunjian , Shi Jian , Zhang Haijun . Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Substituted Tetrazolyl Group[J]. Chinese Journal of Organic Chemistry, 2017 , 37(12) : 3267 -3273 . DOI: 10.6023/cjoc201708026
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