Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (12): 3267-3273.DOI: 10.6023/cjoc201708026 Previous Articles     Next Articles



戴红a, 姚炜a, 杜显超a, 王祥龙a, 吴锦明a, 陈庆文a, 李春建b, 石健b, 张海军a   

  1. a 南通大学化学化工学院 南通 226019;
    b 南通大学分析测试中心 南通 226019
  • 收稿日期:2017-08-13 修回日期:2017-09-06 发布日期:2017-09-26
  • 通讯作者: 吴锦明, 张海军;
  • 基金资助:


Synthesis and Biological Activities of Novel Pyrazole Oxime Derivatives Containing Substituted Tetrazolyl Group

Dai Honga, Yao Weia, Du Xianchaoa, Wang Xianglonga, Wu Jinminga, Chen Qingwena, Li Chunjianb, Shi Jianb, Zhang Haijuna   

  1. a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
    b Analysis and Testing Center, Nantong University, Nantong 226019
  • Received:2017-08-13 Revised:2017-09-06 Published:2017-09-26
  • Contact: 10.6023/cjoc201708026;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), and Postgraduate Research and Practice Innovation Program of Jiangsu Province (No. SJCX17_0640).

In order to explore novel pyrazole oxime derivatives with potent biological activities, a series of novel pyrazole oximes carrying tetrazole unit were designed and synthesized by the method of active substructure combination. The structures of the title compounds were confirmed by 1H NMR,13C NMR, and elemental analysis. Preliminary bioassay data showed that some aimed compounds displayed good insecticidal activities. At the concentration of 500 μg/mL, ten compounds exhibited insecticidal activity against Oriental armyworm with 90%~100%, nine compounds had insecticidal activity against Aphis medicaginis with 80%~100%, ten compounds possessed insecticidal activity against Nilaparvata lugens with 80%~100%, and one compound exhibited 80% acaricidal activity against Tetranychus cinnabarinus. When the concentration was reduced to 100 μg/mL, one compound still showed insecticidal activity against Aphis medicaginis with 85%. Additionally, some compounds had certain fungicidal activity, at 200 μg/mL two compounds showed 60%~80% fungicidal activity against Pseudoperonospora cubensis.

Key words: tetrazole, pyrazole oxime, synthesis, biological activity