Chinese Journal of Organic Chemistry >
Chemical Constituents of Isoflavonoids from Roots of Ficus auriculata
Received date: 2017-09-06
Revised date: 2017-10-12
Online published: 2017-11-15
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 81360478, 21362009), the International S&T Cooperation Program of China (No. 2014DFA40850), the Hainan Special Project for Traditional Chinese Medicine Modernization (No. 2015ZY19), Key Research and Development Project of Hainan Province (No. ZDYF2016139), the Natural Science Foundation of Hainan Province (No. 217177), the Youth Foundation of Hainan Institute of Science and Technology (No. HKYZQJ2014-07), the Hainan Province Innovation Research Project of Graduate Students (No. Hyb2017-33).
Five isoflavonoids were isolated from the roots of the Ficus auriculata by means of silica gel column, HPLC and other chromatography methods. By using spectroscopic techniques including NMR, IR and UV, their structures were identified as 5,7,4'-trihydroxy-8-(1-hydroxy-2,3-epoxy-3-methylbutyl)isoflavone (1), 5,7,4'-trihydroxy-3'-(2,6,7-trihydroxy-3-methylene-7-methyloctyl)isoflavone (2), 5,7,4'-trihydroxy-6-[(S)-2,3-dihydroxy-3-methylbutyl]isoflavone (3), 5,7,4'-trihydroxy-6-pre-nylisoflavone (4), and 5,7,4'-trihydroxy-3'-prenylisoflavone (5). Compounds 1 and 2 were new isoflavonoids. All compounds were evaluated for their anti osteoporosis activities in vitro. Compounds 4 and 5 showed moderate proliferation function of primary osteoblasts in 100 μmol/L.
Shao Taiming , Li Xiaobao , Qi Cuicui , Chen Guangying , Song Xiaoping , Han Changri , Zheng Caijuan . Chemical Constituents of Isoflavonoids from Roots of Ficus auriculata[J]. Chinese Journal of Organic Chemistry, 2018 , 38(3) : 710 -714 . DOI: 10.6023/cjoc201709008
[1] Chinese Flora Editorial Board of Chinese Academy of Sciences Flora of China, Vol. 23, Science Press, Beijing, 1998, p. 170(in Chinese). (中国科学院中国植物志编委会, 中国植物志, 第23卷, 科学出版社, 北京, 1998, p. 170.)
[2] Institute of Medicinal Plant Development Hainan Branch Species List of South China Medicinal Plant Garden, China Agriculture Press, Beijing, 2007, p. 150(in Chinese). (中国医学科学院药用植物研究所海南分所, 南药园植物名录,中国农业出版社, 北京, 2007. p. 150.)
[3] Chiang, Y. M.; Chang, J. Y.; Kuo, C. C.; Kuo, Y. H. Phy-tochemistry 2005, 66, 495.
[4] Parveen, M.; Ghalib, R. M.; Mehdi, S. H.; Rehman, S. H.; Ali, M. Nat. Prod. Res. 2009, 23, 729.
[5] Parveen, M.; Ghalib, R. M.; Mehdi, S. H.; Mattu, R. U. H.; Ali, M. J. Saudi. Chem. Soc. 200913, 287.
[6] Bankeu, J. J. K.; Khayala, R.; Lenta, B. N.; Noungoue, D. T.; Ngouela, A. A. J. Nat. Prod. 2011, 74, 1370.
[7] Kiem, P. V.; Coung, N. X.; Nhiem, N. X.; Thu, V. T.; Ban, N. K.; Tai, B. H.; Kim, Y. H. Bioorg. Med. Chem. Lett. 2011, 21, 633.
[8] Zaffer, B. M.; Mohd, A.; Rasool, M. S. Int. Res. J. Pharm. 2012, 3, 140.
[9] Shao, T. M.; Zheng, C. J.; Han, C. R.; Chen, G. Y.; Dai, C. Y.; Song, X. P.; Zhang, J. C.; Chen, W. H. Bioorg. Med. Chem. Lett. 2014, 24, 3952.
[10] Shao, T. M.; Song, X. P.; Chen, G. Y.; Han, C. R.; Zheng, C. J.; Yao, G. G. Chin. Tradit. Herb. Drug 2013, 44, 2208(in Chinese). (邵泰明, 宋小平, 陈光英, 韩长日, 郑彩娟, 姚国贵, 中草药, 2013, 44, 2208.)
[11] Shao, T. M.; Song, X. P.; Han, C. R.; Chen, G. Y.; Chen, W. H.; Dai, C. Y.; Song, X. M. Nat. Prod. Res. Dev. 2013, 25, 624(in Chinese). (邵泰明, 宋小平, 韩长日, 陈光英, 陈文豪, 戴春燕, 宋鑫明, 天然产物研究与开发, 2013, 25, 624.)
[12] Tian, X. M.; Chen, S. Z.; Tang, L.; Peng, F. T. Helv. Chim. Acta 2008, 91, 1015.
[13] Matsuda, H.; Mofikawa, T.; Xu, F. M.; Ninomiya, K.; Yo-shikawa, M. Planta Med. 2004, 70, 1201.
[14] Li, X. L.; Wang, N. L.; Zhang, X.; Yao, X. S. J. Shenyang Pharm. Univ. 2005, 122, 189(in Chinese). (李晓莉, 王乃利, 张雪, 姚新生, 沈阳药科大学学报, 2005, 122, 189.)
[15] Jiang, B.; Han, W. L.; Zhang, Q. W.; Zhang, X. Q.; Ye, W. C. J. Chin. Med. Mater. 2012, 35, 904(in Chinese). (江蓓, 韩伟立, 张庆文, 张晓琦, 叶文才, 中药材, 2012, 35, 904.)
[16] Moamann, T. J. Immunol. Methods 1983, 65, 55.
/
| 〈 |
|
〉 |
