Chemical Constituents of Isoflavonoids from Roots of Ficus auriculata

doi:10.6023/cjoc201709008

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (3): 710-714.DOI: 10.6023/cjoc201709008 Previous Articles Next Articles

Notes

大果榕根中异黄酮类成分的研究

邵泰明^a,b, 李小宝^a, 祁翠翠^a, 陈光英^a, 宋小平^a, 韩长日^a,b, 郑彩娟^a

a 海南师范大学热带药用植物化学教育部重点实验室海南师范大学化学与化工学院海口 571158;
b 海南省药食同源植物资源重点实验室海南科技职业学院化学与材料工程学院海口 571126

收稿日期:2017-09-06 修回日期:2017-10-12 发布日期:2017-11-15
通讯作者: 宋小平,E-mail:sxp628@126.com;韩长日,E-mail:hchr116@126.com E-mail:sxp628@126.com;hchr116@126.com
基金资助:
国家自然科学基金（Nos.81360478，21362009）、国家国际科技合作专项（No.2014DFA40850）、海南省中药现代化专项（No.2015ZY19）、海南省重点研发计划项目-社会发展（No.ZDYF2016139）、海南省自然科学基金（No.217177）、海南科技职业学院校中青年基金（No.HKYZQJ2014-07）、海南省研究生创新科研课题（No.Hyb2017-33）资助项目.

Chemical Constituents of Isoflavonoids from Roots of Ficus auriculata

Shao Taiming^a,b, Li Xiaobao^a, Qi Cuicui^a, Chen Guangying^a, Song Xiaoping^a, Han Changri^a,b, Zheng Caijuan^a

a Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571127;
b Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, School of Chemical and Material Engineering, Hainan Institute of Science and Technology, Haikou 571126

Received:2017-09-06 Revised:2017-10-12 Published:2017-11-15
Contact: 10.6023/cjoc201709008 E-mail:sxp628@126.com;hchr116@126.com
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 81360478, 21362009), the International S&T Cooperation Program of China (No. 2014DFA40850), the Hainan Special Project for Traditional Chinese Medicine Modernization (No. 2015ZY19), Key Research and Development Project of Hainan Province (No. ZDYF2016139), the Natural Science Foundation of Hainan Province (No. 217177), the Youth Foundation of Hainan Institute of Science and Technology (No. HKYZQJ2014-07), the Hainan Province Innovation Research Project of Graduate Students (No. Hyb2017-33).

1. Chemical Constituents of Isoflavonoids from Roots of Ficus auriculata.PDF(772KB)

Abstract

Five isoflavonoids were isolated from the roots of the Ficus auriculata by means of silica gel column, HPLC and other chromatography methods. By using spectroscopic techniques including NMR, IR and UV, their structures were identified as 5,7,4'-trihydroxy-8-(1-hydroxy-2,3-epoxy-3-methylbutyl)isoflavone (1), 5,7,4'-trihydroxy-3'-(2,6,7-trihydroxy-3-methylene-7-methyloctyl)isoflavone (2), 5,7,4'-trihydroxy-6-[(S)-2,3-dihydroxy-3-methylbutyl]isoflavone (3), 5,7,4'-trihydroxy-6-pre-nylisoflavone (4), and 5,7,4'-trihydroxy-3'-prenylisoflavone (5). Compounds 1 and 2 were new isoflavonoids. All compounds were evaluated for their anti osteoporosis activities in vitro. Compounds 4 and 5 showed moderate proliferation function of primary osteoblasts in 100 μmol/L.

Key words: Ficus auriculata, chemical constituent, isoflavone, anti osteoporosis activity

Cite this article

Shao Taiming, Li Xiaobao, Qi Cuicui, Chen Guangying, Song Xiaoping, Han Changri, Zheng Caijuan. Chemical Constituents of Isoflavonoids from Roots of Ficus auriculata[J]. Chin. J. Org. Chem., 2018, 38(3): 710-714.

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大果榕根中异黄酮类成分的研究

Chemical Constituents of Isoflavonoids from Roots of Ficus auriculata

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