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Synthesis of 3-Acyl and 2-Acyl Imidazo [1, 2-a]pyridines by I2-Mediated Diamination of α, β-Unsaturated Ketones with 2-Aminopyridines
Received date: 2017-12-31
Revised date: 2018-01-11
Online published: 2018-02-06
Supported by
Project supported by the National Natural Science Foundation of China (No. 81330075) and the Outstanding Young Talent Research Fund of Zhengzhou University (No. 1521316004).
Employing molecular iodine as the sole oxidant, a new and transition metal-free diamination reaction of α,β-unsaturated ketones with 2-aminopyridines has been developed. It can not only produce 3-acyl imidazo[1,2-a]pyridines but can also generate novel 2-acyl derivatives regioselectively by changing the solvent and substituents in the 2-aminopyridine substrates.
Yu Wenquan , Song Lina , Tian Xianhai , Zhao Ting , Wang Manman , Wu Jie , Qiao Yan , Chang Junbiao . Synthesis of 3-Acyl and 2-Acyl Imidazo [1, 2-a]pyridines by I2-Mediated Diamination of α, β-Unsaturated Ketones with 2-Aminopyridines[J]. Chinese Journal of Organic Chemistry, 2018 , 38(6) : 1530 -1537 . DOI: 10.6023/cjoc201712045
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