Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (6): 1530-1537.DOI: 10.6023/cjoc201712045 Previous Articles     Next Articles



于文全a, 宋利娜a, 田显海a, 赵婷a, 王漫漫a, 武杰a, 乔艳b, 常俊标a   

  1. a 郑州大学化学与分子工程学院 郑州 450001;
    b 郑州大学基础医学院 郑州 450001
  • 收稿日期:2017-12-31 修回日期:2018-01-11 发布日期:2018-02-06
  • 通讯作者: 于文全,;常俊标,;
  • 基金资助:


Synthesis of 3-Acyl and 2-Acyl Imidazo [1, 2-a]pyridines by I2-Mediated Diamination of α, β-Unsaturated Ketones with 2-Aminopyridines

Yu Wenquana, Song Linaa, Tian Xianhaia, Zhao Tinga, Wang Manmana, Wu Jiea, Qiao Yanb, Chang Junbiaoa   

  1. a College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001;
    b School of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001
  • Received:2017-12-31 Revised:2018-01-11 Published:2018-02-06
  • Contact: 10.6023/cjoc201712045;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 81330075) and the Outstanding Young Talent Research Fund of Zhengzhou University (No. 1521316004).

Employing molecular iodine as the sole oxidant, a new and transition metal-free diamination reaction of α,β-unsaturated ketones with 2-aminopyridines has been developed. It can not only produce 3-acyl imidazo[1,2-a]pyridines but can also generate novel 2-acyl derivatives regioselectively by changing the solvent and substituents in the 2-aminopyridine substrates.

Key words: molecular iodine, transition metal-free, diamination, imidazo[1,2-a]pyridine, regioselective