Chinese Journal of Organic Chemistry >
Mesoporous MCM-41 Supported Schiff Base-Cu(ClO4)2·6H2O Catalyzed Synthesis of Spiro[indole-thiazolidine] Derivatives
Received date: 2018-01-26
Revised date: 2018-04-18
Online published: 2018-05-03
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21362036, 51564045).
Herein, Michael addition-condensation of isatin-3-imines with mercaptoacetic acid to afford a new simple and efficient synthesis of spiro[indole-thiazolidine] derivatives in high yield (up to 99%) by using of MCM-41@Schiff base-Cu(ClO4)2·6H2O as heterogeneous catalyst is reported. In addition, it is found that heterogeneous catalyst exhibits better activity than homogeneous catalyst in the same functional groups. The effect of the pore structure on mesoporous molecular sieve nanoreactor MCM-41 for this reaction is further explored. Consistent activity of recovered catalyst was found to be almost same up to six cycles in 93% yield.
Key words： MCM-41; heterogeneous catalyst; spiro[indole-thiazolidine]; nano-reactors
Hou Yadong , Pang Haixia , Yang Chao , HuiYonghai . Mesoporous MCM-41 Supported Schiff Base-Cu(ClO4)2·6H2O Catalyzed Synthesis of Spiro[indole-thiazolidine] Derivatives[J]. Chinese Journal of Organic Chemistry, 2018 , 38(8) : 2036 -2044 . DOI: 10.6023/cjoc201801039
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