Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (8): 2036-2044.DOI: 10.6023/cjoc201801039 Previous Articles     Next Articles



侯亚东a, 庞海霞a, 杨超a, 惠永海a,b   

  1. a 新疆大学化学化工学院 石油天然气精细化工教育部重点实验室 乌鲁木齐 830046;
    b 岭南师范学院化学化工学院 湛江 524048
  • 收稿日期:2018-01-26 修回日期:2018-04-18 发布日期:2018-05-03
  • 通讯作者: 杨超, 惠永海;
  • 基金资助:


Mesoporous MCM-41 Supported Schiff Base-Cu(ClO4)2·6H2O Catalyzed Synthesis of Spiro[indole-thiazolidine] Derivatives

Hou Yadonga, Pang Haixiaa, Yang Chaoa, HuiYonghaia,b   

  1. a Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046;
    b School of Chemistry and Chemistry Engineering, Lingnan Normal University, Zhanjiang 524048
  • Received:2018-01-26 Revised:2018-04-18 Published:2018-05-03
  • Contact: 10.6023/cjoc201801039;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21362036, 51564045).

Herein, Michael addition-condensation of isatin-3-imines with mercaptoacetic acid to afford a new simple and efficient synthesis of spiro[indole-thiazolidine] derivatives in high yield (up to 99%) by using of MCM-41@Schiff base-Cu(ClO4)2·6H2O as heterogeneous catalyst is reported. In addition, it is found that heterogeneous catalyst exhibits better activity than homogeneous catalyst in the same functional groups. The effect of the pore structure on mesoporous molecular sieve nanoreactor MCM-41 for this reaction is further explored. Consistent activity of recovered catalyst was found to be almost same up to six cycles in 93% yield.

Key words: MCM-41, heterogeneous catalyst, spiro[indole-thiazolidine], nano-reactors