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Chinese Journal of Organic Chemistry >

2018 , Vol. 38 >Issue 8: 1940 - 1948

DOI: https://doi.org/10.6023/cjoc201804004

Reviews

Progress in the Synthesis of Primary Anilines via C-H Bond Functionalization

  • Xu Linlin ,
  • Xu Hui ,
  • Lin Haixia ,
  • Dai Huixiong
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  • a Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444;
    bDepartment of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203;
    c State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Received date: 2018-04-02

  Revised date: 2018-04-23

  Online published: 2018-05-03

Supported by

Project supported by the National Natural Science Foundation of China (No. 21772211) and the Youth Innovation Promotion Association of Chinese Academy of Sciences (No. 2014229).

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Abstract

Primary anilines are widely used in pharmaceutical, agrochemicals and material chemistry. In recent years, the green and efficient methods for constructing carbon-nitrogen (C-N) bonds to introduce primary amines has been one of the hottest topics in chemical synthesis. The direct C-H primary amination of aromatic compounds have received considerable attention due to its high efficiency and practicality. The recent progress in the C-H primary amination of aromatic compounds reactions is reviewed. Furthermore, the synthetic challenge and prospect in the future development for the synthesis of primary anilines through direct C-H amination are summarized.

Key words： amination; C-H bond functionalization; primary anilines; transition-metal catalyzed

Cite this article

Xu Linlin , Xu Hui , Lin Haixia , Dai Huixiong . Progress in the Synthesis of Primary Anilines via C-H Bond Functionalization[J]. Chinese Journal of Organic Chemistry, 2018 , 38(8) : 1940 -1948 . DOI: 10.6023/cjoc201804004

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