Progress in the Synthesis of Primary Anilines via C-H Bond Functionalization

doi:10.6023/cjoc201804004

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (8): 1940-1948.DOI: 10.6023/cjoc201804004 Previous Articles Next Articles

Special Issue: 碳氢活化合辑2018-2019

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基于C-H键官能团化合成芳香伯胺的研究进展

徐琳琳^a, 徐辉^c, 林海霞^a, 戴辉雄^b

a 上海大学化学系上海大学创新药物研究中心上海 200444;
b 中国科学院上海药物研究所药物化学研究室上海 201203;
c 中国科学院上海有机化学研究所金属有机化学国家重点实验室上海 200032

收稿日期:2018-04-02 修回日期:2018-04-23 发布日期:2018-05-03
通讯作者: 林海霞, 戴辉雄 E-mail:haixialin@staff.shu.edu.cn;hxdai@sioc.ac.cn
基金资助:
国家自然科学基金委基金（No.21772211）和中国科学院青年创新促进会（No.2014229）资助项目.

Progress in the Synthesis of Primary Anilines via C-H Bond Functionalization

Xu Linlin^a, Xu Hui^c, Lin Haixia^a, Dai Huixiong^b

a Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444;
bDepartment of Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203;
c State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Received:2018-04-02 Revised:2018-04-23 Published:2018-05-03
Contact: 10.6023/cjoc201804004 E-mail:haixialin@staff.shu.edu.cn;hxdai@sioc.ac.cn
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21772211) and the Youth Innovation Promotion Association of Chinese Academy of Sciences (No. 2014229).

Primary anilines are widely used in pharmaceutical, agrochemicals and material chemistry. In recent years, the green and efficient methods for constructing carbon-nitrogen (C-N) bonds to introduce primary amines has been one of the hottest topics in chemical synthesis. The direct C-H primary amination of aromatic compounds have received considerable attention due to its high efficiency and practicality. The recent progress in the C-H primary amination of aromatic compounds reactions is reviewed. Furthermore, the synthetic challenge and prospect in the future development for the synthesis of primary anilines through direct C-H amination are summarized.

Key words: amination, C-H bond functionalization, primary anilines, transition-metal catalyzed

Cite this article

Xu Linlin, Xu Hui, Lin Haixia, Dai Huixiong. Progress in the Synthesis of Primary Anilines via C-H Bond Functionalization[J]. Chin. J. Org. Chem., 2018, 38(8): 1940-1948.

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基于C-H键官能团化合成芳香伯胺的研究进展

Progress in the Synthesis of Primary Anilines via C-H Bond Functionalization

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