Chinese Journal of Organic Chemistry >
A New Stemodane Diterpenoid from the Stems and Leaves of Trigonostemon heterophyllus
Received date: 2018-04-15
Revised date: 2018-06-03
Online published: 2018-06-29
Supported by
Project supported by the Key Research and Development Project of Hainan Province (No. ZDYF2016221), the Key Research and Development Project of Haikou City (No. 2017050), the National Natural Science Foundation of China (Nos. 21662011, 31660097) and the Program for Innovative Research Team in University (No. IRT-16R19).
A new stemodane diterpenoid, trigoheterone A (1), together with seven known diterpenoids, was isolated from the stems and leaves of Trigonostemon heterophyllus. Their structures were established on the basis of extensive spectral analyses. All known compounds were isolated from the genus Trigonostemon for the first time. The cytotoxicities of all isolated compounds were evaluated against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480). As a result, eight compounds exhibited significant inhibitory effects with IC50 values comparable to those of cisplatin.
Liu Yanping , Zhang Xianglin , Niu Haiyuan , Guan Chunyan , Sun Fukang , Yang Liumeng , Fu Yanhui . A New Stemodane Diterpenoid from the Stems and Leaves of Trigonostemon heterophyllus[J]. Chinese Journal of Organic Chemistry, 2018 , 38(11) : 3137 -3140 . DOI: 10.6023/cjoc201804028
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