Chinese Journal of Organic Chemistry >
I2-Mediated Oxidative C-O Bond Formation for the Synthesis of Isoxazoles
Received date: 2018-06-16
Revised date: 2018-08-02
Online published: 2018-08-23
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 81773570, 81330075) and the Outstanding Young Talent Research Fund of Zhengzhou University (No. 1521316004).
A variety of mono-, di-, and tri-substituted (aryl, alkyl, and/or alkenyl) isoxazoles were synthesized from readily accessible α,β-unsaturated oximes via I2-mediated oxidative C-O bond formation. The features of this synthetic approach include no use of transition metals, simple operation, mild reaction conditions, short reaction time, and broad substrate scope.
Key words： isoxazole; iodine; α,β-unsaturated oxime; C-O bond formation
Hou Jiao , Zhang Xinting , Yu Wenquan , Chang Junbiao . I2-Mediated Oxidative C-O Bond Formation for the Synthesis of Isoxazoles[J]. Chinese Journal of Organic Chemistry, 2018 , 38(12) : 3236 -3241 . DOI: 10.6023/cjoc201806026
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