Chinese Journal of Organic Chemistry >
N-Alkylation of N-H Compounds in N,N-Dimethylformamide Dialkyl Acetal
Received date: 2018-07-04
Revised date: 2018-09-04
Online published: 2018-09-26
Supported by
Project supported by the National First-Class Discipline Program of Food Science and Technology (No. JUFSTR20180101) and the Jiangsu Province Policy Guidance Special Fund (No. BZ2016021).
The N,N-dimethylformamide dialkyl acetal was used as the alkyl source to achieve different nitrogen alkylation reactions of N-H compounds. The reaction has the advantages of cheap raw materials, easy operation, mild reaction conditions, broad substrate scope and no metal participation. By studying the effects of solvents, temperature, reaction time, and the amount of N,N-dimethylformamide dialkyl acetal on the reaction, the optimal reaction conditions were obtained. The effect of different N,N-dimethylformamide dialkyl acetals on the alkylation ability of the substrate was investigated.
Zhao Hui , Zhu Xiaoyun , Hu Xiaoxia , Liu Yan'gea , Tang Chunlei , Feng Bainian . N-Alkylation of N-H Compounds in N,N-Dimethylformamide Dialkyl Acetal[J]. Chinese Journal of Organic Chemistry, 2019 , 39(2) : 434 -442 . DOI: 10.6023/cjoc201807010
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