Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (2): 434-442.DOI: 10.6023/cjoc201807010 Previous Articles     Next Articles



赵辉a, 朱孝云b, 胡小霞a, 刘延革a, 唐春雷a, 冯柏年a   

  1. a 江南大学药学院 无锡 214122;
    b 常州润诺生物科技有限公司 常州 213022
  • 收稿日期:2018-07-04 修回日期:2018-09-04 发布日期:2018-09-26
  • 通讯作者: 唐春雷, 冯柏年;
  • 基金资助:


N-Alkylation of N-H Compounds in N,N-Dimethylformamide Dialkyl Acetal

Zhao Huia, Zhu Xiaoyunb, Hu Xiaoxiaa, Liu Yan'geaa, Tang Chunleia, Feng Bainiana   

  1. a School of Pharmaceutical Science, Jiangnan University, Wuxi 214122;
    b Changzhou Runnuo Biotechnology Co., LTD., Changzhou 213022
  • Received:2018-07-04 Revised:2018-09-04 Published:2018-09-26
  • Contact: 10.6023/cjoc201807010;
  • Supported by:

    Project supported by the National First-Class Discipline Program of Food Science and Technology (No. JUFSTR20180101) and the Jiangsu Province Policy Guidance Special Fund (No. BZ2016021).

The N,N-dimethylformamide dialkyl acetal was used as the alkyl source to achieve different nitrogen alkylation reactions of N-H compounds. The reaction has the advantages of cheap raw materials, easy operation, mild reaction conditions, broad substrate scope and no metal participation. By studying the effects of solvents, temperature, reaction time, and the amount of N,N-dimethylformamide dialkyl acetal on the reaction, the optimal reaction conditions were obtained. The effect of different N,N-dimethylformamide dialkyl acetals on the alkylation ability of the substrate was investigated.

Key words: N,N-dimethylformamide dialkyl acetal, nitrogen alkylation, synthesis