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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 5: 1479 - 1482

DOI: https://doi.org/10.6023/cjoc201812008

Notes

Two New Isocoumarins Isolated from a Mangrove-Derived Fungus Penicillium citrinum HL-5126

  • Mei Rongqing ,
  • Huang Guolei ,
  • Wang Bin ,
  • Bai Meng ,
  • Luo Youping ,
  • Chen Guangying ,
  • Zheng Caijuan
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  • Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158

Received date: 2018-12-05

  Revised date: 2018-12-29

  Online published: 2019-01-18

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21462015, 31760093), the National Natural Science Foundation of Hainan Province (No. 218MS045), the Program for Innovative Research Team in University (No. IRT-16R19).

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Abstract

Two new isocoumarins derivatives, penicimarins J (1) and K (2), were isolated from the mangrove-derived fungus Penicillium citrinum HL-5126. Their structures were elucidated through extensive 1D NMR, 2D NMR and HR-ESI-MS spectroscopic analyses. The absolute configurations of 1 and 2 were determined by comparison of their circular dichroism (CD) spectra with the literature. Compounds 1 and 2 showed inhibitory activities against α-glucosidase with the IC50 values of 18.37 and 25.86 μg/mL, respectively.

Key words： Penicillium citrinum; isocoumarin; antibacterial activity; α-glucosidase inhibitory activity

Cite this article

Mei Rongqing , Huang Guolei , Wang Bin , Bai Meng , Luo Youping , Chen Guangying , Zheng Caijuan . Two New Isocoumarins Isolated from a Mangrove-Derived Fungus Penicillium citrinum HL-5126[J]. Chinese Journal of Organic Chemistry, 2019 , 39(5) : 1479 -1482 . DOI: 10.6023/cjoc201812008

References

[1] Blunt, J. W.; Carroll, A. R.; Copp, B. R.; Davis, R. A.; Keyzer, R. A.; Prinsep, M. R. Nat. Prod. Rep. 2018, 35(1), 8.
[2] Sun, Y. L.; Bao, J.; Liu, K. S.; Zhang, X. Y.; He, F.; Nong, X. H.; Qi, S. H. Planta Med. 2013, 79(15), 1474.
[3] Qi, J.; Shao, C. L.; Liu, M.; Qi, X.; Wang, C. Y. Chem. Nat. Compd. 2014, 50(3), 568.
[4] Asiri, I. A. M.; Badr, J. M.; Youssef, D. T. A. Phytochem. Lett. 2015, 13, 53.
[5] Zheng, C. J.; Huang, G. L.; Xu, Y. Song, X. M.; Yao, J. Liu, H. Wang, R. P.; Song X. P. Nat. Prod. Res. 2016, 30, 821.
[6] Ha, T. M.; Ko, W.; Lee, S. J.; Kim, Y. C.; Son, J. Y.; Sohn, J. H.; Yim, J. H.; Oh, H. Mar. Drugs 2017, 15(9), 282.
[7] Zhou, X. M.; Zheng, C. J.; Chen, G. Y.; Song, X. P.; Han, C. R.; Li, G. N.; Fu, Y. H.; Chen, W. H.; Niu, Z. G. J. Nat. Prod. 2014, 77, 2021.
[8] Liao, H. X.; Sun, D. W.; Zheng, C. J.; Wang, C. Y. Nat. Prod. Res. 2017, 31(14), 1640.
[9] He, K. Y.; Zhang, C.; Duan, Y. R.; Huang, G. L.; Yang, C. Y.; Lu, X. R.; Zheng, C. J; Chen, G. Y. J. Antibiot. 2017, 70, 823.
[10] Zheng, C. J; Wu, L. Y.; Li, X. B.; Song, X. M. Niu, Z. G.; Song, X. P.; Chen, G. Y.; Wang, C. Y. Helv. Chim. Acta 2015, 98, 368.
[11] Zheng, C. J.; Huang, G. L.; Xu, Y.; Song, X. M.; Yao, J. Liu, H.; Wang, R. P.; Song, X. P. Nat. Prod. Res. 2016, 30, 821.
[12] Zheng, C. J.; Bai, M. Zhou, X. M.; Huang, G. L.; Shao, T. M.; Luo, Y. P.; Niu, Z. G.; Niu, Y. Y.; Chen, G. Y.; Han, C. R. J. Nat. Prod. 2018, 81(4), 1045.
[13] Zheng, C. J.; Liao, H. X.; Mei, R. Q.; Huang, G. L.; Yang, L. J.; Zhou, X. M.; Shao, T. M.; Chen, G. Y.; Wang, C. Y. Nat. Prod. Res. 2019, 33, 1127.
[14] Huang, G. L.; Zhou, X. M.; Bai, M.; Liu, Y. X.; Zhao, Y. L.; Luo, Y. P.; Niu, Y. Y.; Zheng, C. J.; Chen, G. Y. Mar. Drugs 2016, 14(10), 177.
[15] Choukchou-Braham, N.; Asakawa, Y.; Lepoittevin, J. P. Tetrahedron Lett. 1994, 35, 3949.
[16] Rivera-Chávez, J.; Figueroa, M.; González, M. D. C.; Glenn, A. E.; Mata, R. J. Nat. Prod. 2015, 78, 730.
[17] Pierce, C. G.; Uppuluri, P.; Teistan, A. R.; Wormley, J. F. L.; Mowat, E.; Ramage, G.; Lopez-ribot, J. L. Nat. Protoc. 2008, 3, 1494.

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