Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (5): 1479-1482.DOI: 10.6023/cjoc201812008 Previous Articles     Next Articles


一株红树来源真菌Penicillium citrinum HL-5126中两个新异香豆素化合物

梅荣清, 黄国雷, 王斌, 白猛, 罗由萍, 陈光英, 郑彩娟   

  1. 热带药用植物化学教育部重点实验室 海南省热带药用植物化学重点实验室 海南师范大学化学与化工学院 海口 571158
  • 收稿日期:2018-12-05 修回日期:2018-12-29 发布日期:2019-01-18
  • 通讯作者: 郑彩娟
  • 基金资助:


Two New Isocoumarins Isolated from a Mangrove-Derived Fungus Penicillium citrinum HL-5126

Mei Rongqing, Huang Guolei, Wang Bin, Bai Meng, Luo Youping, Chen Guangying, Zheng Caijuan   

  1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
  • Received:2018-12-05 Revised:2018-12-29 Published:2019-01-18
  • Contact: 10.6023/cjoc201812008
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21462015, 31760093), the National Natural Science Foundation of Hainan Province (No. 218MS045), the Program for Innovative Research Team in University (No. IRT-16R19).

Two new isocoumarins derivatives, penicimarins J (1) and K (2), were isolated from the mangrove-derived fungus Penicillium citrinum HL-5126. Their structures were elucidated through extensive 1D NMR, 2D NMR and HR-ESI-MS spectroscopic analyses. The absolute configurations of 1 and 2 were determined by comparison of their circular dichroism (CD) spectra with the literature. Compounds 1 and 2 showed inhibitory activities against α-glucosidase with the IC50 values of 18.37 and 25.86 μg/mL, respectively.

Key words: Penicillium citrinum, isocoumarin, antibacterial activity, α-glucosidase inhibitory activity