Chinese Journal of Organic Chemistry >
Cytotoxic Secondary Metabolites from an Endophytic Fungal Strain of Phomopsis phyllanthicola
Received date: 2018-12-06
Revised date: 2019-01-09
Online published: 2019-01-31
Supported by
Project supported by the National Natural Science Foundation of China (No. 31600271), the Guangdong Provincial Project for Science and Technology (No. 2107A020211023), and the Pearl River Science and Technology New Star Fund of Guangzhou City (No. 201806010080).
The chemical investigation of the broth extract of the endophytic fungus Phomopsis phyllanthicola A658, which was isolated from the medicinal plant Pogostemon cablin, resulted in the isolation of one new compound, named dothiorelone O (1) and one new natural product 2-(3,5-dihydroxy-2-(7-hydroxyoctanoyl)phenyl)acetic acid (2), along with four known derivatives. Their structures were fully characterized by means of detailed spectroscopic analysis for new structures, and in comparison with published data for known compounds. Moreover, all of the compounds were evaluated for in vitro cytotoxic activities against SF-268, MCF-7, HepG-2, and A549 tumor cell lines.
Liu Hongxin , Li Haohua , Chen Yuchan , Tan Haibo , Zhang Weimin . Cytotoxic Secondary Metabolites from an Endophytic Fungal Strain of Phomopsis phyllanthicola[J]. Chinese Journal of Organic Chemistry, 2019 , 39(5) : 1475 -1478 . DOI: 10.6023/cjoc201812009
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