Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (5): 1475-1478.DOI: 10.6023/cjoc201812009 Previous Articles     Next Articles



刘洪新a, 李浩华a, 陈玉蝉a, 谭海波b, 章卫民a   

  1. a 广东省微生物研究所 省部共建华南应用微生物国家重点实验室 广东省菌种保藏与应用重点实验室 广东省微生物应用新技术公共实验室 广州 510070;
    b 中国科学院华南植物园 广州 510650
  • 收稿日期:2018-12-06 修回日期:2019-01-09 发布日期:2019-01-31
  • 通讯作者: 章卫民
  • 基金资助:


Cytotoxic Secondary Metabolites from an Endophytic Fungal Strain of Phomopsis phyllanthicola

Liu Hongxina, Li Haohuaa, Chen Yuchana, Tan Haibob, Zhang Weimina   

  1. a State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070;
    b South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650
  • Received:2018-12-06 Revised:2019-01-09 Published:2019-01-31
  • Contact: 10.6023/cjoc201812009
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 31600271), the Guangdong Provincial Project for Science and Technology (No. 2107A020211023), and the Pearl River Science and Technology New Star Fund of Guangzhou City (No. 201806010080).

The chemical investigation of the broth extract of the endophytic fungus Phomopsis phyllanthicola A658, which was isolated from the medicinal plant Pogostemon cablin, resulted in the isolation of one new compound, named dothiorelone O (1) and one new natural product 2-(3,5-dihydroxy-2-(7-hydroxyoctanoyl)phenyl)acetic acid (2), along with four known derivatives. Their structures were fully characterized by means of detailed spectroscopic analysis for new structures, and in comparison with published data for known compounds. Moreover, all of the compounds were evaluated for in vitro cytotoxic activities against SF-268, MCF-7, HepG-2, and A549 tumor cell lines.

Key words: Pogostemon cablin, endophytic fungus, Phomopsis phyllanthicola, cytotoxicity