Chinese Journal of Organic Chemistry >
Tin Powder Promoted Synthesis of α-Trifluoromethyl Homoallylic Hydrazides
Received date: 2019-01-07
Revised date: 2019-01-29
Online published: 2019-02-22
Supported by
Project supported by the National Natural Science Foundation of China (Nos. 21861033, 21462037).
An efficient multicomponent one-pot reaction was developed for the synthesis of α-trifluoromethyl homoallylic hydrazides from the reactions of ethyl trifluoropyruvate, hydrazides and allylic bromide with tin powder in the presence of Brønsted and Lewis acid in 1,4-dioxane under reflux. The method avoids the use of toxic stannanes and allows easy operation. The reaction proceeds smoothly under mild reaction conditions to give the corresponding products in good yields.
Liu Jiaxin , Huang Danfeng , Wang Xiaoping , Zong Wuzhong , Su Yingpeng , Wang Kehu , Hu Yulai . Tin Powder Promoted Synthesis of α-Trifluoromethyl Homoallylic Hydrazides[J]. Chinese Journal of Organic Chemistry, 2019 , 39(6) : 1767 -1775 . DOI: 10.6023/cjoc201901007
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