Tin Powder Promoted Synthesis of α-Trifluoromethyl Homoallylic Hydrazides

doi:10.6023/cjoc201901007

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (6): 1767-1775.DOI: 10.6023/cjoc201901007 Previous Articles Next Articles

Special Issue: 元素有机化学合辑2018-2019

Articles

锡粉促进下α-三氟甲基高烯丙基酰肼的合成

刘佳欣, 黄丹凤, 王小平, 宗吴中, 苏瀛鹏, 王克虎, 胡雨来

西北师范大学化学化工学院兰州 730070

收稿日期:2019-01-07 修回日期:2019-01-29 发布日期:2019-02-22
通讯作者: 黄丹凤 E-mail:huangdf@nwnu.edu.cn
基金资助:
国家自然科学基金（Nos.21861033，21462037）资助项目.

Tin Powder Promoted Synthesis of α-Trifluoromethyl Homoallylic Hydrazides

Liu Jiaxin, Huang Danfeng, Wang Xiaoping, Zong Wuzhong, Su Yingpeng, Wang Kehu, Hu Yulai

College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Received:2019-01-07 Revised:2019-01-29 Published:2019-02-22
Contact: 10.6023/cjoc201901007 E-mail:huangdf@nwnu.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21861033, 21462037).

1. Tin Powder Promoted Synthesis of α-Trifluoromethyl Homoallylic Hydrazides.PDF(13054KB)

Abstract

An efficient multicomponent one-pot reaction was developed for the synthesis of α-trifluoromethyl homoallylic hydrazides from the reactions of ethyl trifluoropyruvate, hydrazides and allylic bromide with tin powder in the presence of Brønsted and Lewis acid in 1,4-dioxane under reflux. The method avoids the use of toxic stannanes and allows easy operation. The reaction proceeds smoothly under mild reaction conditions to give the corresponding products in good yields.

Key words: one-pot, tin powder, ethyl trifluoropyruvate, α-trifluoromethyl homoallylic hydrazides

Cite this article

Liu Jiaxin, Huang Danfeng, Wang Xiaoping, Zong Wuzhong, Su Yingpeng, Wang Kehu, Hu Yulai. Tin Powder Promoted Synthesis of α-Trifluoromethyl Homoallylic Hydrazides[J]. Chin. J. Org. Chem., 2019, 39(6): 1767-1775.

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锡粉促进下α-三氟甲基高烯丙基酰肼的合成

Tin Powder Promoted Synthesis of α-Trifluoromethyl Homoallylic Hydrazides

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