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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 8: 2333 - 2337

DOI: https://doi.org/10.6023/cjoc201903036

Notes

NaBH4/I2-Mediated Efficient Iodination of Alcohols

  • Fan Zhengning ,
  • Zhang Bo ,
  • Xi Chanjuan
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  • a Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084;
    b State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071

Received date: 2019-03-20

  Revised date: 2019-04-17

  Online published: 2019-04-26

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21871163, 91645120).

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Abstract

A simple, mild, and high yielding procedure for the iodination of alcohols using a combination of NaBH4 and I2 is described. The effectiveness of the protocol is achieved with benzylic alcohols and primary alkylic alcohols whereas allylic and secondary alcohols are found to be unreactive.

Key words： alcohol; iodide; sodium borohydride; iodination

Cite this article

Fan Zhengning , Zhang Bo , Xi Chanjuan . NaBH4/I2-Mediated Efficient Iodination of Alcohols[J]. Chinese Journal of Organic Chemistry, 2019 , 39(8) : 2333 -2337 . DOI: 10.6023/cjoc201903036

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