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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 10: 2685 - 2704

DOI: https://doi.org/10.6023/cjoc201903058

REVIEW

Progress in Total Syntheses of Dimeric Cyclotryptamine Alkaloids

  • Xianfu Shen ,
  • Tianfeng Peng ,
  • Yongyun Zhou ,
  • Yongkai Xi ,
  • Jingfeng Zhao ,
  • Xiaodong Yang ,
  • Hongbin Zhang
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  • a Center for Yunnan-Guizhou Plateau Chemical Functional Materials and Pollution Control, College of Biological Resource and Food Engineering, Qujing Normal University, Qujing 655011, Yunnan
    b Key Laboratory of Natural Products Transformation and Utilization in Yunnan Province, Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, Kunming 650091

Received date: 2019-03-26

  Revised date: 2019-04-18

  Online published: 2019-05-10

Supported by

Project supported by the Program for Changjiang Scholars and Innovative Research Team in University(IRT17R94);The National Natural Science Foundation of China(2152197);The National Natural Science Foundation of China(21861032);The Natural Science Foundation of Yunnan Province(2018FD078);The Natural Science Foundation of Yunnan Province(2017FH001-020);The Qujing Normal University(2018QN002)

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Abstract

As interesting synthetic targets, dimeric cyclotryptamine alkaloids bearing sterically hindered vicinal all-carbon quaternary stereocenters have attracted significant attention from the synthetic community. Stereocontrolled synthesis of the congested all-carbon quaternary stereocenters in these alkaloids presents a formidable challenge. This review summarizes the synthetic efforts towards dimeric cyclotryptamine alkaloids in the last twelve years.

Key words： dimeric cyclotryptamine; alkaloids; vicinal quaternary carbons; oxindole; total synthesis

Cite this article

Xianfu Shen , Tianfeng Peng , Yongyun Zhou , Yongkai Xi , Jingfeng Zhao , Xiaodong Yang , Hongbin Zhang . Progress in Total Syntheses of Dimeric Cyclotryptamine Alkaloids[J]. Chinese Journal of Organic Chemistry, 2019 , 39(10) : 2685 -2704 . DOI: 10.6023/cjoc201903058

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