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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 10: 2851 - 2859

DOI: https://doi.org/10.6023/cjoc201904049

ARTICLE

Synthesis and Biological Activities of New 4-PhenylanilinesContaining the Diphenyl Ether Moiety

  • Wanqiang Wang ,
  • Lan Cheng ,
  • Hongying Peng ,
  • Weizhong Yao ,
  • Rui Zhang ,
  • Cheng Chen ,
  • Hua Cheng
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  • a Department of Chemical Engineering and Food Science, Hubei University of Arts and Science, Xiangyang 441053
    b State Key Laboratory of Advanced Technology for Materials Synthesis and Processing,Wuhan University of Technology, Wuhan 430070

Received date: 2019-04-19

  Revised date: 2019-05-23

  Online published: 2019-06-06

Supported by

Project supported by the National Natural Science Foundation of China(21502062);The Teachers' Scientific Research Ability Cultivation Fund of Hubei University of Arts and Science(2018kypy001);The Open Foundation of Discipline of Hubei University of Arts and Science(XK2019039)

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Abstract

According to the principle of "splicing-up" bioactive substructures, a new series of target compounds were designed and synthesized by incorporating a diphenyl ether moiety into 4-phenylanilines. Moreover, the structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR, HRMS and melting points measurements. The inhibitory activities of these compounds were evaluated against succinate-cytochrome reductase (SCR). Based on the bioassay results, target compound N-(4-(2-chloro-4-(trifluoromethyl)phenoxy)-3-fluorophenyl)-[1,1'-biphenyl]-4-amine (3o) exhibited an inhibition rate of 46.44% at a concentration of 10 μmol?L –1, which demonstrated potential values for further investigations.

Key words： 4-phenylanilines; diphenyl ether; synthesis; biological activities

Cite this article

Wanqiang Wang , Lan Cheng , Hongying Peng , Weizhong Yao , Rui Zhang , Cheng Chen , Hua Cheng . Synthesis and Biological Activities of New 4-PhenylanilinesContaining the Diphenyl Ether Moiety[J]. Chinese Journal of Organic Chemistry, 2019 , 39(10) : 2851 -2859 . DOI: 10.6023/cjoc201904049

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