Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (10): 2851-2859.DOI: 10.6023/cjoc201904049 Previous Articles     Next Articles



汪万强a, 程兰a, 彭宏英a, 姚维忠a, 张锐a, 陈宬b*(), 程华a*()   

  1. a 湖北文理学院化学化工与食品科学学院 襄阳 441053
    b 武汉理工大学材料复合新技术国家重点实验室 武汉 430070
  • 收稿日期:2019-04-19 修回日期:2019-05-23 发布日期:2019-06-06
  • 通讯作者: 陈宬,程华;
  • 基金资助:

Synthesis and Biological Activities of New 4-PhenylanilinesContaining the Diphenyl Ether Moiety

Wang Wanqianga, Cheng Lana, Peng Hongyinga, Yao Weizhonga, Zhang Ruia, Chen Chengb*(), Cheng Huaa*()   

  1. a Department of Chemical Engineering and Food Science, Hubei University of Arts and Science, Xiangyang 441053
    b State Key Laboratory of Advanced Technology for Materials Synthesis and Processing,Wuhan University of Technology, Wuhan 430070
  • Received:2019-04-19 Revised:2019-05-23 Published:2019-06-06
  • Contact: Chen Cheng,Cheng Hua;
  • Supported by:
    Project supported by the National Natural Science Foundation of China(21502062);The Teachers' Scientific Research Ability Cultivation Fund of Hubei University of Arts and Science(2018kypy001);The Open Foundation of Discipline of Hubei University of Arts and Science(XK2019039)

According to the principle of "splicing-up" bioactive substructures, a new series of target compounds were designed and synthesized by incorporating a diphenyl ether moiety into 4-phenylanilines. Moreover, the structures of the synthesized compounds were confirmed by 1H NMR, 13C NMR, HRMS and melting points measurements. The inhibitory activities of these compounds were evaluated against succinate-cytochrome reductase (SCR). Based on the bioassay results, target compound N-(4-(2-chloro-4-(trifluoromethyl)phenoxy)-3-fluorophenyl)-[1,1'-biphenyl]-4-amine (3o) exhibited an inhibition rate of 46.44% at a concentration of 10 μmol?L –1, which demonstrated potential values for further investigations.

Key words: 4-phenylanilines, diphenyl ether, synthesis, biological activities