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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 11: 3223 - 3229

DOI: https://doi.org/10.6023/cjoc201904051

Triethylamine Promoted the C-C Bond Cleavage of α-Halo Ketones: α-Acetoxyaryl Ketone Synthesis

  • Maorui Wang ,
  • Yuzheng Wu ,
  • Jian Yao ,
  • Li Deng ,
  • Yingming Pan ,
  • Kebin Huang ,
  • Haitao Tang
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  • State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, Guangxi 541004

Received date: 2019-04-22

  Online published: 2019-07-03

Supported by

the National Natural Science Foundation of China(21362002);the Bagui Scholar Program of Guangxi Province of China(2016A13)

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Abstract

The cleavage of C-C bonds is a key method for synthesis of useful intermediates. A novel amine-promoted C-C bond cleavage of α-halo ketones was reported. Oxidant-free and metal-free conditions are the striking features of the protocol. In this simple method, a variety of α-acetoxyaryl ketone compounds were prepared from commercially available α-halo ketones in good to excellent yields.

Key words： cleavage of C-C bonds; α-halo ketones; oxidant-free and metal-free; α-acetoxyaryl ketone

Cite this article

Maorui Wang , Yuzheng Wu , Jian Yao , Li Deng , Yingming Pan , Kebin Huang , Haitao Tang . Triethylamine Promoted the C-C Bond Cleavage of α-Halo Ketones: α-Acetoxyaryl Ketone Synthesis[J]. Chinese Journal of Organic Chemistry, 2019 , 39(11) : 3223 -3229 . DOI: 10.6023/cjoc201904051

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