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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 11: 3294 - 3298

DOI: https://doi.org/10.6023/cjoc201903007

Iron/O2-Promoted C-H Bond Functionalization for the Exclusive Synthesis of 2-Quinoline Carboxaldehydes under Microwave Irradiation

  • Tinghui Xie ,
  • Xiaoying Jiang ,
  • Zhisheng Mi ,
  • Xue Li ,
  • Xiaohe Xu ,
  • Renren Bai ,
  • Qi Shuai ,
  • Yuanyuan Xie
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  • a Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceutical, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014
    b College of Agriculture and Bioengineering, Taizhou Vocational College of Science and Technology, Taizhou, Zhejiang 318020

Received date: 2019-03-04

  Online published: 2019-07-09

Supported by

the National Natural Science Foundation of China(21576239)

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Abstract

An one-pot iron-catalyzed oxidative formylation of 2-methylquinolines to produce 2-quinoline carboxaldehydes under microwave irradiation has been achieved by employing O2 as the oxygen donor. The reaction was general for the substrates with a wide range of functional groups, providing a yield of 48%~80%. The preliminary mechanistic studies revealed that the reaction underwent a radical pathway. Advantages of this method include the easy operation, short reaction time and good selectivity.

Key words： 2-quinoline carboxaldehydes; iron catalysis; C-H oxidation; microwave irradiation

Cite this article

Tinghui Xie , Xiaoying Jiang , Zhisheng Mi , Xue Li , Xiaohe Xu , Renren Bai , Qi Shuai , Yuanyuan Xie . Iron/O2-Promoted C-H Bond Functionalization for the Exclusive Synthesis of 2-Quinoline Carboxaldehydes under Microwave Irradiation[J]. Chinese Journal of Organic Chemistry, 2019 , 39(11) : 3294 -3298 . DOI: 10.6023/cjoc201903007

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