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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 11: 3169 - 3175

DOI: https://doi.org/10.6023/cjoc201904028

High-Selective One-Pot Synthesis of Spirocyclopropane Pyrazolones Promoted by 4-Dimethylaminopyridine

  • Jie Liang ,
  • Huifang Ma ,
  • Keyume Ablajan
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  • Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046

Received date: 2019-04-10

  Online published: 2019-07-09

Supported by

the National Natural Science Foundation of Chin(21961038);the National Natural Science Foundation of Chin(21462041)

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Abstract

A 4-dimethylaminopyridine (DMAP)-promoted high stereoselectivity method for the synthesis of polysubstituted spiropropane pyrazolone was developed. A series of target compounds were synthesized from using pyrazolone, aromatic aldehyde and bromoacetate as raw materials, and DMAP as a base with high yield via three-component one-pot reaction. This reaction has the advantages of simple operation, high yield and good diastereotopic selectivity. In addition, this synthetic method is of great value for the study of spiropropane.

Key words： one-pot synthesis; multicomponent reactions; spirocyclopropane; pyrazolones; 4-dimethylaminopyridine (DMAP)

Cite this article

Jie Liang , Huifang Ma , Keyume Ablajan . High-Selective One-Pot Synthesis of Spirocyclopropane Pyrazolones Promoted by 4-Dimethylaminopyridine[J]. Chinese Journal of Organic Chemistry, 2019 , 39(11) : 3169 -3175 . DOI: 10.6023/cjoc201904028

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