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Chinese Journal of Organic Chemistry >

2019 , Vol. 39 >Issue 12: 3583 - 3587

DOI: https://doi.org/10.6023/cjoc201904066

Chemical Constituents from Hypericum Erectum Thunb

  • Li Jun ,
  • Xu Xiaoshi ,
  • Teng Haida ,
  • Chen Yu ,
  • Mei Zhinan ,
  • Yang Guangzhong
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  • a School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074;
    b College of Chemistry and Materials Sciences, South-Central University for Nationalities, Wuhan 430074

Received date: 2019-04-26

  Revised date: 2019-06-17

  Online published: 2019-07-17

Supported by

Project supported by the National Major New Drugs Innovation and Development (No. 2017ZX09301060) and the Special Fund for Basic Scientific Research of Central Colleges, South-Central University for Nationalities (No. CZP18004).

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Abstract

The chemical constituents of Hypericum erectum Thunb were isolated and purified by solvent extraction method, the normal and reverse phase silica gel column chromatography and semi-preparative high performance liquid chromatography. Their structures were elucidated by their physicochemical property and extensive analysis of spectroscopic data. Three new compounds which belong to α-pyranone, flavonoid and aliphatic alcohol respectively, together with 15 known compounds, were isolated from the chloroform extract of H. erectum. Inflammatory cell model was constructed by lipopolysaccharide (LPS)-stimulated RAW264.7 cell line. NO production inhibitory effects of all tested compounds were measured by Griess method. Hyperiflavone (2), isocudraniaxan-thone B (5) and 2-deprenylrheediaxanthone B (6) exhibited moderate NO production inhibitory activities with the IC50 values of 16.24, 9.86 and 12.90 μmol·L-1, respectively.

Key words： Hypericum Linn; Hypericum erectum Thunb; xanthone; anti-inflammatory activity

Cite this article

Li Jun , Xu Xiaoshi , Teng Haida , Chen Yu , Mei Zhinan , Yang Guangzhong . Chemical Constituents from Hypericum Erectum Thunb[J]. Chinese Journal of Organic Chemistry, 2019 , 39(12) : 3583 -3587 . DOI: 10.6023/cjoc201904066

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