Chemical Constituents from Hypericum Erectum Thunb

doi:10.6023/cjoc201904066

Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (12): 3583-3587.DOI: 10.6023/cjoc201904066 Previous Articles Next Articles

小连翘化学成分的研究

李竣^a, 徐晓诗^a, 滕海达^b, 陈玉^b, 梅之南^a, 杨光忠^a

a 中南民族大学药学院武汉 430074;
b 中南民族大学化学与材料科学学院武汉 430074

收稿日期:2019-04-26 修回日期:2019-06-17 发布日期:2019-07-17
通讯作者: 梅之南, 杨光忠 E-mail:meizhinan@163.com;yanggz888@126.com
基金资助:
国家重大新药创制科技重大专项（No.2017Z09301060）和中央高校基本科研业务费（No.CZP18004）资助项目.

Chemical Constituents from Hypericum Erectum Thunb

Li Jun^a, Xu Xiaoshi^a, Teng Haida^b, Chen Yu^b, Mei Zhinan^a, Yang Guangzhong^a

a School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074;
b College of Chemistry and Materials Sciences, South-Central University for Nationalities, Wuhan 430074

Received:2019-04-26 Revised:2019-06-17 Published:2019-07-17
Supported by:
Project supported by the National Major New Drugs Innovation and Development (No. 2017ZX09301060) and the Special Fund for Basic Scientific Research of Central Colleges, South-Central University for Nationalities (No. CZP18004).

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Abstract

The chemical constituents of Hypericum erectum Thunb were isolated and purified by solvent extraction method, the normal and reverse phase silica gel column chromatography and semi-preparative high performance liquid chromatography. Their structures were elucidated by their physicochemical property and extensive analysis of spectroscopic data. Three new compounds which belong to α-pyranone, flavonoid and aliphatic alcohol respectively, together with 15 known compounds, were isolated from the chloroform extract of H. erectum. Inflammatory cell model was constructed by lipopolysaccharide (LPS)-stimulated RAW264.7 cell line. NO production inhibitory effects of all tested compounds were measured by Griess method. Hyperiflavone (2), isocudraniaxan-thone B (5) and 2-deprenylrheediaxanthone B (6) exhibited moderate NO production inhibitory activities with the IC₅₀ values of 16.24, 9.86 and 12.90 μmol·L^-1, respectively.

Key words: Hypericum Linn, Hypericum erectum Thunb, xanthone, anti-inflammatory activity

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Li Jun, Xu Xiaoshi, Teng Haida, Chen Yu, Mei Zhinan, Yang Guangzhong. Chemical Constituents from Hypericum Erectum Thunb[J]. Chinese Journal of Organic Chemistry, 2019, 39(12): 3583-3587.

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小连翘化学成分的研究

Chemical Constituents from Hypericum Erectum Thunb

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