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Chinese Journal of Organic Chemistry >

2020 , Vol. 40 >Issue 1: 1 - 14

DOI: https://doi.org/10.6023/cjoc201907028

Recent Progress on Direct Difluoromethylthiolation and Monofluoromethylthiolation

  • Yan Qiang ,
  • Jiang Lüqi ,
  • Yi Wenbin
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  • Chemical Engineering College, Nanjing University of Science and Technology, Nanjing 210094

Received date: 2019-07-20

  Revised date: 2019-08-29

  Online published: 2019-09-12

Supported by

Project supported by the National Natural Science Foundation of China (No. 21476116), the Fundamental Research Funds for the Central Universities (No. 30918011314), the Natural Science Foundation of Jiangsu Province (No. BK20141394) and the Qing Lan and Six Talent Peaks in Jiangsu Province.

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Abstract

Compounds bearing difluoromethylthio (SCF2H) and monofluoromethylthio (SCFH2) groups are potentially important targets in the pharmaceutical and agrochemical fields due to their unique physical and chemical properties. The traditional methods of synthesizing these two kinds of compounds are difluoromethylation and monofluoromethylation of sulfhydryl substrates. However, the limitation of sulfhydryl substrates also limited the application and development of such compounds. Thus, it is still highly desirable to develop new methods for difluoromethylthiolation and monofluoromethylthiolation as well as new types of difluoromethylthiolation and monofluoromethylthiolation reagents. The recent development of direct difluoromethylthiolation and monofluoromethylthiolation reactions is summarized, and the related mechanism are also discussed.

Key words： difluoromethylthiolation; monofluoromethylthiolation; direct method

Cite this article

Yan Qiang , Jiang Lüqi , Yi Wenbin . Recent Progress on Direct Difluoromethylthiolation and Monofluoromethylthiolation[J]. Chinese Journal of Organic Chemistry, 2020 , 40(1) : 1 -14 . DOI: 10.6023/cjoc201907028

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