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Chinese Journal of Organic Chemistry >

2020 , Vol. 40 >Issue 1: 181 - 185

DOI: https://doi.org/10.6023/cjoc201907039

A Fluorescent Probe for Hydrazine Based on Synergistic Effect and Its Utilization in Cell Imaging

  • Xu Wenzhi ,
  • Li Xue ,
  • Han Mengnan ,
  • Zhou Tingting ,
  • Yang Yutao ,
  • Li Wei
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  • Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry & Environmental Science, Hebei University, Baoding, Hebei 071002

Received date: 2019-07-26

  Revised date: 2019-08-28

  Online published: 2019-09-25

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21702043, 21807021).

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Abstract

Hydrazine is an important raw material and catalyst in chemical industry. However, hydrazine is very harmful to human organs. A new type of probe was developed based on the synergistic effect. Two recognition sites were introduced into the probe to improve performance to hydrazine, which has good specificity to hydrazine. The limit of detection (LOD) for N2H4 was 0.05~10.0 μmol·L-1. Moreover, the probe could detect N2H4 in BT-474 cells.

Key words： hydrazine; synergistic effect; cell imaging; fluorescent probe

Cite this article

Xu Wenzhi , Li Xue , Han Mengnan , Zhou Tingting , Yang Yutao , Li Wei . A Fluorescent Probe for Hydrazine Based on Synergistic Effect and Its Utilization in Cell Imaging[J]. Chinese Journal of Organic Chemistry, 2020 , 40(1) : 181 -185 . DOI: 10.6023/cjoc201907039

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