Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (1): 181-185.DOI: 10.6023/cjoc201907039 Previous Articles     Next Articles


胥稳智, 李雪, 韩孟楠, 周婷婷, 杨瑜涛, 李玮   

  1. 河北大学化学与环境科学学院 药物化学与分子诊断教育部重点实验室 河北省化学生物学重点实验室 河北保定 071002
  • 收稿日期:2019-07-26 修回日期:2019-08-28 发布日期:2019-09-25
  • 通讯作者: 胥稳智, 李玮;
  • 基金资助:

A Fluorescent Probe for Hydrazine Based on Synergistic Effect and Its Utilization in Cell Imaging

Xu Wenzhi, Li Xue, Han Mengnan, Zhou Tingting, Yang Yutao, Li Wei   

  1. Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education, Key Laboratory of Chemical Biology of Hebei Province, College of Chemistry & Environmental Science, Hebei University, Baoding, Hebei 071002
  • Received:2019-07-26 Revised:2019-08-28 Published:2019-09-25
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21702043, 21807021).

Hydrazine is an important raw material and catalyst in chemical industry. However, hydrazine is very harmful to human organs. A new type of probe was developed based on the synergistic effect. Two recognition sites were introduced into the probe to improve performance to hydrazine, which has good specificity to hydrazine. The limit of detection (LOD) for N2H4 was 0.05~10.0 μmol·L-1. Moreover, the probe could detect N2H4 in BT-474 cells.

Key words: hydrazine, synergistic effect, cell imaging, fluorescent probe