Study on the Hydrocyanation Reaction of Trifluoromethylated Acylhydrazones

  • Xu Weigang ,
  • Huang Danfeng ,
  • Wang Kehu ,
  • Zhao Fangxia ,
  • Zhao Zhuanxia ,
  • Hu Yongqing ,
  • Su Yingpeng ,
  • Hu Yulai
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  • College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Received date: 2019-10-11

  Revised date: 2019-12-10

  Online published: 2019-12-27

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21662030, 21861033).

Abstract

The Lewis acid catalyzed 1,2-addition reaction of trifluoromethylated acylhydrazones with trimethylsilyl cyanide was investigated, and a series of cyanohydrazide compounds containing trifluoromethyl group were afforded in high yield. The method could be easily operated in mild reaction conditions, which provides an efficient method for the synthesis of trifluoromethylated hydrazides with structural diversity.

Cite this article

Xu Weigang , Huang Danfeng , Wang Kehu , Zhao Fangxia , Zhao Zhuanxia , Hu Yongqing , Su Yingpeng , Hu Yulai . Study on the Hydrocyanation Reaction of Trifluoromethylated Acylhydrazones[J]. Chinese Journal of Organic Chemistry, 2020 , 40(4) : 922 -929 . DOI: 10.6023/cjoc201910011

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