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Chinese Journal of Organic Chemistry >

2020 , Vol. 40 >Issue 7: 1901 - 1911

DOI: https://doi.org/10.6023/cjoc202001012

Recent Advances of the Construction of Trifluoromethylated Quaternary Carbon Center

  • Wang Shoufeng ,
  • Wang Wengui
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  • Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022

Received date: 2020-01-07

  Revised date: 2020-03-24

  Online published: 2020-04-10

Supported by

Project supported by the National Natural Science Foundation of China (No. 31972850) and the Shandong Provincial Key Research Program (No. 2019GSF108223).

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Abstract

Trifluoromethyl is an important group, which is often used in pharmecuticals and agrochemicals. Quaternary carbon centers are widely existed in natural products and synthetic compounds. Recently, the construction of molecules containing trifluoromethylated quaternary carbon centers has been developed rapidly. Starting with direct trifluoromethylation, new synthons and new reactions, the research progress of the synthesis of trifluoromethylated quaternary carbon centers is reviewed.

Key words： trifluoromethyl; quaternary carbon center; research progress

Cite this article

Wang Shoufeng , Wang Wengui . Recent Advances of the Construction of Trifluoromethylated Quaternary Carbon Center[J]. Chinese Journal of Organic Chemistry, 2020 , 40(7) : 1901 -1911 . DOI: 10.6023/cjoc202001012

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