Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (7): 1901-1911.DOI: 10.6023/cjoc202001012 Previous Articles     Next Articles


王守锋, 王文贵   

  1. 济南大学化学化工学院 山东省氟化学化工材料重点实验室 济南 250022
  • 收稿日期:2020-01-07 修回日期:2020-03-24 发布日期:2020-04-10
  • 通讯作者: 王守锋, 王文贵;
  • 基金资助:

Recent Advances of the Construction of Trifluoromethylated Quaternary Carbon Center

Wang Shoufeng, Wang Wengui   

  1. Shandong Provincial Key Laboratory of Fluorine Chemistry and Chemical Materials, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022
  • Received:2020-01-07 Revised:2020-03-24 Published:2020-04-10
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 31972850) and the Shandong Provincial Key Research Program (No. 2019GSF108223).

Trifluoromethyl is an important group, which is often used in pharmecuticals and agrochemicals. Quaternary carbon centers are widely existed in natural products and synthetic compounds. Recently, the construction of molecules containing trifluoromethylated quaternary carbon centers has been developed rapidly. Starting with direct trifluoromethylation, new synthons and new reactions, the research progress of the synthesis of trifluoromethylated quaternary carbon centers is reviewed.

Key words: trifluoromethyl, quaternary carbon center, research progress