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Chinese Journal of Organic Chemistry >

2020 , Vol. 40 >Issue 7: 2142 - 2147

DOI: https://doi.org/10.6023/cjoc202003032

N-Iodo-succininide (NIS)/K2S2O8 Initiated Self-Coupling of Enamides to Nitrogen-Containing Quaternary Carbon Centers

  • Zhou Xiaoqiang ,
  • Yan Hao ,
  • Wang Qiuya
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  • a College of Chemistry and Material, Weinan Normal University, Weinan, Shaanxi 714099;
    b State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000;
    c College of pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046

Received date: 2020-03-12

  Revised date: 2020-03-29

  Online published: 2020-04-17

Supported by

Project supported by the Natural Science Basic Research Program of Shaanxi Province (No. 2019JQ-902), the Scientific Research Program Funded by Shaanxi Provincial Education Department (No. 19JK0287), and the Scientific Research Foundation of Weinan Normal University (Nos. 18ZRRC05, 17ZRRC04).

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Abstract

N-Iodo-succininide (NIS)/K2S2O8 initiated C-C bond formation reaction through self-coupling of enamides has been reported. The environmental friendliness and high atom-economy of this transition-metal free radical pathway offers a useful and attractive strategy to nitrogen-containing quaternary carbon centers.

Key words： quaternary carbon centers; enamides; C-C bond formation; iodide; radical addition; transition-metal free

Cite this article

Zhou Xiaoqiang , Yan Hao , Wang Qiuya . N-Iodo-succininide (NIS)/K2S2O8 Initiated Self-Coupling of Enamides to Nitrogen-Containing Quaternary Carbon Centers[J]. Chinese Journal of Organic Chemistry, 2020 , 40(7) : 2142 -2147 . DOI: 10.6023/cjoc202003032

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