Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (7): 2142-2147.DOI: 10.6023/cjoc202003032 Previous Articles     Next Articles


周小强a,b, 闫浩b,c, 王秋亚a   

  1. a 渭南师范学院化学与材料学院 陕西渭南 714099;
    b 兰州大学功能有机分子化学国家重点实验室 兰州 730000;
    c 陕西中医药大学药学院 陕西咸阳 712046
  • 收稿日期:2020-03-12 修回日期:2020-03-29 发布日期:2020-04-17
  • 通讯作者: 周小强
  • 基金资助:

N-Iodo-succininide (NIS)/K2S2O8 Initiated Self-Coupling of Enamides to Nitrogen-Containing Quaternary Carbon Centers

Zhou Xiaoqianga,b, Yan Haob,c, Wang Qiuyaa   

  1. a College of Chemistry and Material, Weinan Normal University, Weinan, Shaanxi 714099;
    b State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000;
    c College of pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046
  • Received:2020-03-12 Revised:2020-03-29 Published:2020-04-17
  • Supported by:
    Project supported by the Natural Science Basic Research Program of Shaanxi Province (No. 2019JQ-902), the Scientific Research Program Funded by Shaanxi Provincial Education Department (No. 19JK0287), and the Scientific Research Foundation of Weinan Normal University (Nos. 18ZRRC05, 17ZRRC04).

N-Iodo-succininide (NIS)/K2S2O8 initiated C-C bond formation reaction through self-coupling of enamides has been reported. The environmental friendliness and high atom-economy of this transition-metal free radical pathway offers a useful and attractive strategy to nitrogen-containing quaternary carbon centers.

Key words: quaternary carbon centers, enamides, C-C bond formation, iodide, radical addition, transition-metal free