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Chinese Journal of Organic Chemistry >

2020 , Vol. 40 >Issue 11: 3760 - 3776

DOI: https://doi.org/10.6023/cjoc202003061

Recent Progress in Applications of Vinylaziridines in Organic Synthesis

  • Wu Yali ,
  • Zhou Xuesong ,
  • Xiao Wenjing ,
  • Chen Jiarong
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  • College of Chemistry, Central China Normal University, Wuhan 430079

Received date: 2020-03-27

  Revised date: 2020-04-26

  Online published: 2020-04-30

Supported by

Project supported by the National Natural Science Foundation of China (Nos. 21971081, 91856119).

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Abstract

Due to its alkene moiety and highly strained aziridine scaffold, vinylaziridines represent a versatile type of synthetic building blocks and can undergo various chemcial transformations. These transformations enabled facile synthesis of a wide range of nitrogen-containing compounds, especially diverse nitrogen heterocycles, inculding azetidines, pyrrolidines, piperidines, azacycloheptanes and so on. Moreover, development of simple and efficient synthetic methods for various substituted vinylaziridines, stimulating their applications in the fields of organic synthesis, medicinal and agrochemistry, as well as fine chemistry. In recent years, such type of reagents continue to attract considerable research efforts from chemists and enjoyed rapid development. The representative examples of nucleophilic ring-opening and cyclization reactions of vinyl-aziridines over the past five years are summarized. Moreover, the prospects of further development are also disscussed.

Key words： vinylaziridines; aziridines; ring-opening reaction; cyclization reaction; nitrogen heterocycles

Cite this article

Wu Yali , Zhou Xuesong , Xiao Wenjing , Chen Jiarong . Recent Progress in Applications of Vinylaziridines in Organic Synthesis[J]. Chinese Journal of Organic Chemistry, 2020 , 40(11) : 3760 -3776 . DOI: 10.6023/cjoc202003061

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